Clopidol Testing in Feed and Food

Clopidol is a synthetic coccidiostat used in poultry production to control coccidiosis. Unlike ionophores, clopidol does not act through ion transport disruption but interferes with the energy metabolism of Eimeria parasites.
It has been used for many years in structured coccidiosis control programmes and may be incorporated into broiler and other poultry feeds at regulated inclusion levels.

Clopidol is typically included in premixes and compound feeds where consistent control of coccidial infection is required. As with other coccidiostats, accurate dosing and uniform mixing are essential to ensure both efficacy and safety.
Its use may form part of rotation strategies designed to maintain long-term parasite control.

Improper handling during feed manufacture can lead to compliance risks, particularly where multiple medicated feeds are produced on shared equipment.
Risk factors include:
‣ Over-inclusion
‣ Cross-contamination
‣ Inadequate flushing procedures
‣ Residue non-compliance
Regulatory authorities define authorised inclusion levels and compliance requirements to safeguard animal and consumer health.

Analytical testing provides objective confirmation that clopidol levels meet authorised specifications and that carry-over remains controlled.
Routine verification supports:
‣ Label claim confirmation
‣ Cross-contamination monitoring
‣ Internal quality control systems
LC-MS/MS methods enable accurate quantification of clopidol in premix and compound feed matrices.